Characteristics and Outcomes of Chinese Children With Advanced Stage Anaplastic Large Cell Lymphoma: A Single-Center Experience.

ABSTRACT:

Purpose

To evaluate the clinical characteristics and treatment outcomes of Chinese children with advanced stage anaplastic large cell lymphoma (ALCL) who were treated with the low-intensity APO regimen.

Methods

Clinical data from children newly diagnosed with advanced stage ALCL and treated with the APO regimen were reviewed.

Results

Altogether 22 eligible patients with advanced stage ALCL were recruited in this study. 18 (81%) patients achieved complete response (CR) after the initial induction, and 4 experienced relapse. Among patients with relapsed or refractory ALCL, CR was achieved in 3 (50%) who received the BFM95 R3/R4 regimen. Besides, 2 patients received the targeted therapy with crizotinib and were still alive. The 5-year OS and EFS rates were 82 ± 8.7% and

SUBMITTER: Zhang YT 

PROVIDER: S-EPMC8885804 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature