Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy.

ABSTRACT: Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and second COVID-19 vaccine doses, and again 3 months following the second dose, in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525-935) cells/mm³, though nadir CD4+ T-cell counts ranged as low as <10 cells/mm³. After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was associated with lower anti-RBD antibody concentrations and ACE2 displacement activity

SUBMITTER: Brumme ZL 

PROVIDER: S-EPMC8885829 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature