Lifetime stressor exposure, systemic inflammation during pregnancy, and preterm birth among Black American women.

ABSTRACT: Although Black American mothers and infants are at higher risk for morbidity and mortality than their White counterparts, the biological mechanisms underlying these phenomena remain largely unknown. To investigate the role that lifetime stressor exposure, perceived stressor severity, and systemic inflammatory markers might play, we studied how these factors were interrelated in 92 pregnant Black American women. We also compared inflammatory marker levels for women who did versus did not go on to give birth preterm. During the early third trimester, women completed the Stress and Adversity Inventory for Adults to assess the stressors they experienced over their lifetime. Women also provided blood samples for plasma interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α quantific

SUBMITTER: Gillespie SL 

PROVIDER: S-EPMC8885874 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature