GDF15: a potential therapeutic target for type 1 diabetes.

ABSTRACT:

Introduction

Current treatment for type 1 diabetes (T1D) is centered around insulin supplementation to manage the effects of pancreatic β cell loss. GDF15 is a potential preventative therapy against T1D progression that could work to curb increasing disease incidence.

Areas covered

This paper discusses the known actions of GDF15, a pleiotropic protein with metabolic, feeding, and immunomodulatory effects, connecting them to highlight the open opportunities for future research. The role of GDF15 in the prevention of insulitis and protection of pancreatic β cells against pro-inflammatory cytokine-mediated cellular stress are examined and the pharmacological promise of GDF15 and critical areas of future research are discussed.

Expert opinion

GDF15 shows promise as a pote

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC8885880 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature