Treating Cardiovascular Disease with Liver Genome Engineering.

ABSTRACT:

Purpose of review

This review examines recent progress in somatic genome editing for cardiovascular disease. We briefly highlight new gene editing approaches, delivery systems, and potential targets in the liver.

Recent findings

In recent years, new editing and delivery systems have been applied successfully in model organisms to modify genes within hepatocytes. Disruption of several genes has been shown to dramatically lower plasma cholesterol and triglyceride levels in mice as well as non-human primates. More precise modification of cardiovascular targets has also been achieved through homology-directed repair or base editing. Improved viral vectors and nanoparticle delivery systems are addressing important delivery challenges and helping to mitigate safety concerns. Liver

SUBMITTER: Hurley A 

PROVIDER: S-EPMC8886347 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature