Association Between Generic-to-Generic Levothyroxine Switching and Thyrotropin Levels Among US Adults.

ABSTRACT:

Importance

Switching among generic levothyroxine sodium products made by different manufacturers typically occurs at the pharmacy and may affect serum thyrotropin (TSH) levels.

Objective

To compare TSH levels between patients who continued taking the same sourced generic levothyroxine product and those who switched.

Design, setting, and participants

This comparative effectiveness research study with 1:1 propensity matching used data from OptumLabs Data Warehouse, a national administrative claims database linked to laboratory test results. Adults aged 18 years or older were included if they filled a generic levothyroxine prescription between January 1, 2008, and June 30, 2019, and had a stable drug dose, the same drug manufacturer, and a normal TSH level (0.3-4.4 mIU/L

SUBMITTER: Brito JP 

PROVIDER: S-EPMC8886450 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature