Transcutaneous Flexible Sensor for In Vivo Photonic Detection of pH and Lactate.

ABSTRACT: Clinical research shows that frequent measurements of both pH and lactate can help guide therapy and improve patient outcome. However, current methods of sampling blood pH and lactate make it impractical to take readings frequently (due to the heightened risk of blood infection and anemia). As a solution, we have engineered a subcutaneous pH and lactate sensor (PALS) that can provide continuous, physiologically relevant measurements. To measure pH, a sheet containing a pH-sensitive fluorescent dye is placed over 400 and 465 nm light-emitting diodes (LEDs) and a filter-coated photodetector. The filter-coated photodetector collects an emitted signal from the dye for each LED excitation, and the ratio of the emitted signals is used to monitor pH. To measure lactate, two sensing sheets compris

SUBMITTER: Nguyen D 

PROVIDER: S-EPMC8886565 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature