Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients.

ABSTRACT: Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one's actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the tempor

SUBMITTER: Salomon R 

PROVIDER: S-EPMC8886583 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature