A Global Phosphorylation Atlas of Proteins Within Pathological Site of Rotator Cuff Tendinopathy.

ABSTRACT: Rotator cuff tendinopathy (RCT) is the most common cause of shoulder pain, therefore posing an important clinical problem. Understanding the mechanism and biochemical changes of RCT would be of crucial importance and pave the path to targeting novel and effective therapeutic strategies in translational perspectives and clinical practices. Phosphorylation, as one of the most important and well-studied post-translational modifications, is tightly associated with protein activity and protein functional regulation. Here in this study, we generated a global protein phosphorylation atlas within the pathological site of human RCT patients. By using Tandem Mass Tag (TMT) labeling combined with mass spectrometry, an average of 7,741 phosphorylation sites (p-sites) and 3,026 proteins were identified

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8886731 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature