Comprehensive analysis of ferroptosis-related genes and prognosis of cutaneous melanoma.

ABSTRACT:

Background

Cutaneous Melanoma (CM) is a malignant disease with increasing incidence and high mortality. Ferroptosis is a new kind of cell death and related to tumor blood and lymphatic metastasis. This study aims at using bioinformatics technology to construct a prognostic signature and identify ferroptosis-related biomarkers to improve the prognosis and treatment of cutaneous melanoma.

Methods

We used bioinformatics tools to analyze RNA sequencing expression data with clinical information from multiple databases, utilized varieties of statistical methods to construct a ferroptosis-related prognostic signature of cutaneous melanoma and screened out specific genes with independent prognostic ability.

Results

We obtained 22 ferroptosis-related (P < 0.05) prognostic DEGs

SUBMITTER: Liu C 

PROVIDER: S-EPMC8886785 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature