Proton density water fraction as a reproducible MR-based measurement of breast density.

ABSTRACT:

Purpose

To introduce proton density water fraction (PDWF) as a confounder-corrected (CC) MR-based biomarker of mammographic breast density, a known risk factor for breast cancer.

Methods

Chemical shift encoded (CSE) MR images were acquired using a low flip angle to provide proton density contrast from multiple echo times. Fat and water images, corrected for known biases, were produced by a six-echo CC CSE-MRI algorithm. Fibroglandular tissue (FGT) volume was calculated from whole-breast segmented PDWF maps at 1.5T and 3T. The method was evaluated in (1) a physical fat-water phantom and (2) normal volunteers. Results from two- and three-echo CSE-MRI methods were included for comparison.

Results

Six-echo CC-CSE-MRI produced unbiased estimates of the total water volume i

SUBMITTER: Henze Bancroft LC 

PROVIDER: S-EPMC8886798 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature