NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity.

ABSTRACT: Neurons are polarized cells of extreme scale and compartmentalization. To fulfill their role in electrochemical signaling, axons must maintain a specific complement of membrane proteins. Despite being the subject of considerable attention, the trafficking pathway of axonal membrane proteins is not well understood. Two pathways, direct delivery and transcytosis, have been proposed. Previous studies reached contradictory conclusions about which of these mediates delivery of axonal membrane proteins to their destination, in part because they evaluated long-term distribution changes and not vesicle transport. We developed a novel strategy to selectively label vesicles in different trafficking pathways and determined the trafficking of two canonical axonal membrane proteins, neuron-glia cell ad

SUBMITTER: Nabb AT 

PROVIDER: S-EPMC8886818 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature