The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.

ABSTRACT:

Background

Methylated SDC2 and TFPI2 are widely used for colorectal cancer (CRC) detection. However, they often miss some CRCs, which directly diminishes the sensitivity. Further investigations of the underlying mechanisms leading to the missed samples will facilitate developing more eligible methylation markers.

Methods

CRC samples from TCGA and GEO datasets were divided into three groups, High-methylation/ High-methylation (HH), High-methylation/Low-methylation (HL), and Low-methylation/Low-methylation (LL) according to the methylation status of SDC2 and TFPI2 promoters. Variations in age, tumor location and microsatellite instable were then assessed between the three groups and verified in our custom cohort.

Results

Samples of HL group preferred to derive from left

SUBMITTER: Lei R 

PROVIDER: S-EPMC8886827 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature