Transmission of Antimicrobial Resistant Yersinia pestis During a Pneumonic Plague Outbreak.

ABSTRACT:

Background

Pneumonic plague (PP), caused by Yersinia pestis, is the most feared clinical form of plague due to its rapid lethality and potential to cause outbreaks. PP outbreaks are now rare due to antimicrobial therapy.

Methods

A PP outbreak in Madagascar involving transmission of a Y. pestis strain resistant to streptomycin, the current recommended first-line treatment in Madagascar, was retrospectively characterized using epidemiology, clinical diagnostics, molecular characterization, and animal studies.

Results

The outbreak occurred in February 2013 in the Faratsiho district of Madagascar and involved 22 cases, including 3 untreated fatalities. The 19 other cases participated in funeral practices for the fatal cases and fully recovered after combination antimicrob

SUBMITTER: Andrianaivoarimanana V 

PROVIDER: S-EPMC8886911 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature