Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).

ABSTRACT: Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. Objectives: To evaluate effects of a 12-month partially supervised PA intervention using motivational feedback. Methods: In a parallel-arm multicenter randomized controlled trial (ACTIVATE-CF), relatively inactive patients aged at least 12 years were randomly assigned (1:1 ratio) to an intervention group or control group. The intervention group consented to add 3 hours of vigorous PA per week, whereas the control group was asked not to change their PA behavior. Primary endpoint was change in percent predicted FEV₁ (ΔFEV₁) at 6 months. Secondary endpoints included PA, exercise capacity, exercise motives, time to first exacerbation an

SUBMITTER: Hebestreit H 

PROVIDER: S-EPMC8887001 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature