Safety of light emitting diode-red light on human skin: Two randomized controlled trials.

ABSTRACT: Therapeutic applications of light emitting diode-red light (LED-RL) are expanding, yet data on its clinical effects are lacking. Our goal was to evaluate the safety of high fluence LED-RL (≥160 J/cm² ). In two phase I, single-blind, dose escalation, randomized controlled trials, healthy subjects received LED-RL or mock irradiation to the forearm thrice weekly for 3 weeks at fluences of 160-640 J/cm² for all skin types (STARS 1, n = 60) and at 480-640 J/cm² for non-Hispanic Caucasians (STARS 2, n = 55). The primary outcome was the incidence of adverse events (AEs). The maximum tolerated dose was the highest fluence that did not elicit predefined AEs. Dose-limiting AEs, including blistering and prolonged erythema, occurred at 480 J/cm² in STARS 1 (

SUBMITTER: Jagdeo J 

PROVIDER: S-EPMC8887049 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature