Neoadjuvant chemotherapy for patients with locally advanced penile cancer: an updated evidence.

ABSTRACT: Neoadjuvant chemotherapy (NAC) has shown promising results in patients with locally advanced penile cancer. However, no consensus exists on its applications for locally advanced penile cancer. Thus, it is unclear which kind of chemotherapy regimen is the best choice. Consequently, a systematic search of PubMed, Web of Science, and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile cancer. The Newcastle-Ottawa Scale was used to assess the risk of bias in each study. This study synthesized 14 published studies. The study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective response. In addition, the objective r

SUBMITTER: Yi XY 

PROVIDER: S-EPMC8887093 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature