Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis.

ABSTRACT:

Background

Bacterial vaginosis-a condition defined by a shift from Lactobacillus dominance to a polymicrobial, anaerobic bacterial community-increases the risk of acquiring sexually transmitted infections and other complications of the female reproductive tract. Antibiotic treatment frequently fails to return the microbiome to an optimal Lactobacillus-dominated state. No criteria currently exist to identify the patients likely to experience treatment failure.

Objective

We sought to identify the pretreatment community signatures associated with treatment failure through 16S ribosomal RNA gene analysis.

Study design

Twenty-eight women who were enrolled in an oral metronidazole treatment trial of bacterial vaginosis were studied. Cervicovaginal lavage samples were collec

SUBMITTER: Gustin AT 

PROVIDER: S-EPMC8887553 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature