Downregulation of ALDH6A1 is a New Marker of Muscle Insulin Resistance in Type 2 Diabetes Mellitus.

ABSTRACT:

Purpose

Skeletal muscle insulin resistance (IR) is an important etiology of type 2 diabetes mellitus (T2DM); however, its molecular mechanism is yet to be fully defined. This study attempted to identify the gene expression patterns and molecular disorders in T2DM patients' skeletal muscle samples.

Methods

First, the difference in genetic expression among GSE25462 data was analyzed. Next, PPI network analysis of differential genes was carried out, after which the maladjustment module was identified. Then, an enrichment analysis and gene set enrichment analysis (GSEA) were carried out. Finally, the transcription factors that regulate the modular genes by raid were predicted.

Results

Most differentially expressed genes were found to be able to form an interaction network

SUBMITTER: Liu S 

PROVIDER: S-EPMC8887615 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature