Inference is bliss: Simulation for power estimation for an observational study of a cholera outbreak intervention.

ABSTRACT:

Background

The evaluation of ring vaccination and other outbreak-containment interventions during severe and rapidly-evolving epidemics presents a challenge for the choice of a feasible study design, and subsequently, for the estimation of statistical power. To support a future evaluation of a case-area targeted intervention against cholera, we have proposed a prospective observational study design to estimate the association between the strength of implementation of this intervention across several small outbreaks (occurring within geographically delineated clusters around primary and secondary cases named 'rings') and its effectiveness (defined as a reduction in cholera incidence). We describe here a strategy combining mathematical modelling and simulation to estimate power for a

SUBMITTER: Ratnayake R 

PROVIDER: S-EPMC8887757 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature