Development and Validation of a Model for Prediction of End-Stage Liver Disease in People With HIV.

ABSTRACT:

Background

End-stage liver disease (ESLD) is a leading cause of non-AIDS-related death among people with HIV (PWH). Factors that increase the progression of liver disease include comorbidities and HIV-specific factors, but we currently lack a tool to apply this evidence into clinical practice.

Methods

We developed and validated a risk prediction model for ESLD among PWH who received care in 12 cohorts of the North American AIDS Cohort Collaboration on Research and Design between 2000 and 2016 and had fibrosis-4 index > 1.45. The first occurrence of ascites, variceal bleed, spontaneous bacterial peritonitis, or hepatic encephalopathy was verified by standardized medical record review. The Bayesian model averaging was used to select predictors among biomarkers and diagnoses an

SUBMITTER: Kim HN 

PROVIDER: S-EPMC8887786 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature