Effect of alginate matrix engineered to mimic the pancreatic microenvironment on encapsulated islet function.

ABSTRACT: Islet transplantation is emerging as a therapeutic option for type 1 diabetes, albeit, only a small number of patients meeting very stringent criteria are eligible for the treatment because of the side effects of the necessary immunosuppressive therapy and the relatively short time frame of normoglycemia that most patients achieve. The challenge of the immune-suppressive regimen can be overcome through microencapsulation of the islets in a perm-selective coating of alginate microbeads with poly-l-lysine or poly- l-ornithine. In addition to other issues including the nutrient supply challenge of encapsulated islets a critical requirement for these cells has emerged as the need to engineer the microenvironment of the encapsulation matrix to mimic that of the native pancreatic scaffold that h

SUBMITTER: Enck K 

PROVIDER: S-EPMC8887826 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature