Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition.

ABSTRACT: Parvalbumin-positive (PV⁺) γ-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations, but the significance of PV⁺ axon myelination to the temporal features of inhibition remains elusive. Here, using toxic and genetic mouse models of demyelination and dysmyelination, respectively, we find that loss of compact myelin reduces PV⁺ interneuron presynaptic terminals and increases failures, and the weak phasic inhibition of pyramidal neurons abolishes optogenetically driven gamma oscillations in vivo. Strikingly, during behaviors of quiet wakefulness selectively theta rhythms are amplified and accompanied by highly synchronized interictal epileptic discharges. In support of a caus

SUBMITTER: Dubey M 

PROVIDER: S-EPMC8887893 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature