The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges.

ABSTRACT:

Background

Effective treatments for COVID-19 are urgently needed, but conducting randomized trials during the pandemic has been challenging.

Methods

The Anti-Coronavirus Therapy (ACT) trials are parallel factorial international trials that aimed to enroll 3500 outpatients and 2500 inpatients with symptomatic COVID-19. The outpatient trial is evaluating colchicine vs usual care, and aspirin vs usual care. The primary outcome for the colchicine randomization is hospitalization or death, and for the aspirin randomization, it is major thrombosis, hospitalization, or death. The inpatient trial is evaluating colchicine vs usual care, and the combination of rivaroxaban 2.5 mg twice daily and aspirin 100 mg once daily vs usual care. The primary outcome for the colchicine randomizati

SUBMITTER: Eikelboom J 

PROVIDER: S-EPMC8887957 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature