Amphiphilic small molecular mates match hydrophobic drugs to form nanoassemblies based on drug-mate strategy.

ABSTRACT: Nanomedicine has made great progress in the targeted therapy of cancer. Here, we established a novel drug-mate strategy by studying the formulation of nanodrugs at the molecular level. In the drug-mate combination, the drug is a hydrophobic drug that is poorly soluble in water, and the mate is an amphiphilic small molecule (SMA) that has both hydrophilic and lipophilic properties. We proposed that the hydrophobic drug could co-assemble with a suitable SMA on a nanoscale without additive agents. The proof-of-concept methodology and results were presented to support our hypothesis. We selected five hydrophobic drugs and more than ten amphiphilic small molecules to construct a library. Through molecular dynamic simulation and quantum chemistry computation, we speculated that the formation of

SUBMITTER: Han L 

PROVIDER: S-EPMC8888179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature