Tris(2-Pyridylmethylamine)V(O)₂ Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity.

ABSTRACT: The synthesis and theoretical-experimental characterization of a novel diprotanated decavanadate is presented here due to our search for novel anticancer metallodrugs. Tris(2-pyridylmethyl)amine (TPMA), which is also known to have anticancer activity in osteosarcoma cell lines, was introduced as a possible cationic species that could act as a counterpart for the decavanadate anion. However, the isolated compound contains the previously reported vanadium (V) dioxido-tpma moieties, and the decavanadate anion appears to be diprotonated. The structural characterization of the compound was performed by infrared spectroscopy and single-crystal X-ray diffraction. In addition, DFT calculations were used to analyze the reactive sites involved in the donor-acceptor interactions from the molecular el

SUBMITTER: Corona-Motolinia ND 

PROVIDER: S-EPMC8888438 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature