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Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA⁺ Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM⁺ Cell Signature.

ABSTRACT: Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system that results in demyelination of axons, inefficient signal transmission and reduced muscular mobility. Recent findings suggest that B cells play a significant role in disease development and pathology. To further explore this, B cell profiles in peripheral blood from 28 treatment-naive patients with early MS were assessed using flow cytometry and compared to 17 healthy controls. Conventional and algorithm-based analysis revealed a significant increase in MS patients of IgA⁺ memory B cells (MBC) including CD27⁺, CD27^- and Tbet⁺ subsets. Screening circulating B cells for markers associated with B cell function revealed a significantly decreased expressi

SUBMITTER: Leffler J

PROVIDER: S-EPMC8888440 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA⁺ Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM⁺ Cell Signature.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA+ Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM+ Cell Signature.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA⁺ Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM⁺ Cell Signature.