Machine learning-based pathomics signature could act as a novel prognostic marker for patients with clear cell renal cell carcinoma.

ABSTRACT:

Background

Traditional histopathology performed by pathologists through naked eyes is insufficient for accurate survival prediction of clear cell renal cell carcinoma (ccRCC).

Methods

A total of 483 whole slide images (WSIs) data from three patient cohorts were retrospectively analyzed. We performed machine learning algorithm to identify optimal digital pathological features and constructed machine learning-based pathomics signature (MLPS) for ccRCC patients. Prognostic performance of the prognostic model was also verified in two independent validation cohorts.

Results

MLPS could significantly distinguish ccRCC patients with high survival risk, with hazard ratio of 15.05, 4.49 and 1.65 in three independent cohorts, respectively. Cox regression analysis revealed that t

SUBMITTER: Chen S 

PROVIDER: S-EPMC8888584 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature