Modeling assortative mating and genetic similarities between partners, siblings, and in-laws.

ABSTRACT: Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners (n = 26,681), siblings (n = 2,170), siblings-in-law (n = 3,905), and co-siblings-in-law (n = 1,763) in the Norwegian Mother, Father and Child Cohort Study. Using structural equation models, we estimated associations between measurement error-free latent genetic and phenotypic variables. We found evidence of genetic similarity between partners for educational attainment (r_g = 0.37), height (r_g = 0.13), and depression (r_g = 0.08). Common genetic variants associated with educational attainment correlated between siblings above 0.50 (r_g =

SUBMITTER: Torvik FA 

PROVIDER: S-EPMC8888605 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature