Regional variations in hepatocellular carcinoma incidence, routes to diagnosis, treatment and survival in England.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) incidence, management and survival across England were examined to determine if geographical inequalities exist.

Method

15,468 HCC cases diagnosed 2010-2016 were included. Age-standardised incidence rates, net survival and proportions receiving potentially curative treatment and presenting through each route to diagnosis adjusted for age at diagnosis, sex and area-based deprivation quintile, were calculated overall and by Cancer Alliance.

Results

HCC incidence rates increased in men from 6.2 per 100,000 in 2010 to 8.8 in 2016, and in women from 1.5 to 2.2. The highest incidence rates, found in parts of the North of England and London, were nearly double the lowest. The adjusted proportion presenting as an emergency ranged 27-4

SUBMITTER: Burton A 

PROVIDER: S-EPMC8888669 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature