Genes Involved in Maintaining Mitochondrial Membrane Potential Upon Electron Transport Chain Disruption.

ABSTRACT: Mitochondria are biosynthetic, bioenergetic, and signaling organelles with a critical role in cellular physiology. Dysfunctional mitochondria are associated with aging and underlie the cause of a wide range of diseases, from neurodegeneration to cancer. Through signaling, mitochondria regulate diverse biological outcomes. The maintenance of the mitochondrial membrane potential, for instance, is essential for proliferation, the release of mitochondrial reactive oxygen species, and oxygen sensing. The loss of mitochondrial membrane potential triggers pathways to clear damaged mitochondria and often results in cell death. In this study, we conducted a genome-wide positive selection CRISPR screen using a combination of mitochondrial inhibitors to uncover genes involved in sustaining a mitochon

SUBMITTER: Vasan K 

PROVIDER: S-EPMC8888678 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature