Exploiting mesothelin in thymic carcinoma as a drug delivery target for anetumab ravtansine.

ABSTRACT:

Background

Thymic epithelial tumours (TETs) are rare tumours comprised of thymomas and thymic carcinoma. Novel therapies are needed, especially in thymic carcinoma where the 5-year survival rate hovers at 30%. Mesothelin (MSLN), a surface glycoprotein that is cleaved to produce mature MSLN (mMSLN) and megakaryocyte potentiating factor (MPF), is expressed in limited tissues. However, its expression is present in various cancers, including thymic carcinoma, where it is expressed in 79% of cases.

Methods

We utilised flow cytometry, in vitro cytotoxicity assays, and an in vivo xenograft model in order to demonstrate the ability of the MSLN targeting antibody-drug conjugate (ADC) anetumab ravtansine (ARav) in inhibiting the growth of thymic carcinoma.

Results

Thymoma and t

SUBMITTER: Chen V 

PROVIDER: S-EPMC8888701 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature