Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer's Disease Patients.

ABSTRACT:

Background and objective

Inflammatory mediators are closely associated with the pathogenesis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Netrin-1 is an axon guidance protein and despite its capacity to function as a neuroimmune guidance signal, its role in AD or MCI is poorly understood. In addition, the association among netrin-1, cognitive impairment and serum inflammatory cytokines such as interleukin-17 (IL-17) and tumor necrosis (TNF-α) remains unclear. The aim of this study was to determine serum levels of IL-17, TNF-α and netrin-1in a cohort of AD and MCI patients, and to study the relationship between these cytokines and cognitive status, as well as to assess the possible relationships between netrin-1 levels and inflammatory molecules.

Methods

S

SUBMITTER: Ju T 

PROVIDER: S-EPMC8888826 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature