Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components.

ABSTRACT:

Introduction and objectives

Genome-wide association studies have identified a high number of genetic loci associated with hypertension suggesting the presence of an underlying polygenic architecture. In this study, we aimed to dissect the polygenic component of primary hypertension searching also for pathway-specific components.

Methods

The polygenic risk score (PRS) models, based on the UK biobank genetic signals for hypertension status, were obtained on a target Italian case/control cohort including 561 cases and 731 hyper-normal controls from HYPERGENES, and were then applied to an independent validation cohort composed by multi-countries European-based samples including 1,284 cases and 960 hyper-normal controls.

Results

The resulting genome-wide PRS was capable of

SUBMITTER: Maj C 

PROVIDER: S-EPMC8888857 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature