The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy.

ABSTRACT:

Objective

Emerging research highlights the importance of basal-temporal cortex, centered on the fusiform gyrus, to both pre-surgical naming ability and post-surgical naming outcomes in temporal lobe epilepsy (TLE). In this study, we investigate whether integrity of the white matter network that interconnects this basal region to the distributed language network affects naming ability and risk for post-surgical naming decline.

Methods

Patients with drug-resistant TLE were recruited from two epilepsy centers in a prospective longitudinal study. The pre-surgical dataset included 50 healthy controls, 47 left TLE (L-TLE), and 41 right TLE (R-TLE) patients. All participants completed pre-surgical T1- and diffusion-weighted MRI (dMRI), as well as neuropsychological tests of auditor

SUBMITTER: Kaestner E 

PROVIDER: S-EPMC8888987 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature