Women have higher levels of CoQ₁₀ than men when supplemented with a single dose of CoQ₁₀ with monoglycerides omega-3 or rice oil and followed for 48 h: a crossover randomised triple blind controlled study.

ABSTRACT: Coenzyme Q₁₀ (CoQ₁₀), a lipid involved in ATP synthesis, exhibits very limited oral absorption, and its endogenous production decreases with ageing and with the occurrence of oxidative stress. Our group previously showed that monoglycerides omega-3 (MAG-OM3) increase OM3 plasma concentrations. Since CoQ₁₀ is liposoluble, we hypothesised that its 48 h pharmacokinetics is higher when provided with MAG-OM3 compared to CoQ₁₀ alone (in powder form) or added to rice oil (a neutral triacylglycerol oil). A randomised triple-blind crossover study was performed with fifteen men and fifteen women consuming the three supplements providing 200 mg of CoQ₁₀ in a random order. Blood samples were collected before (t = 0) and 1, 3, 5, 6, 7, 8, 10

SUBMITTER: Beaulieu S 

PROVIDER: S-EPMC8889221 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature