Recombinant CD300c-Ig fusion protein attenuates collagen-induced arthritis in mice.

ABSTRACT:

Objectives

RA is a chronic autoimmune disease characterized by joint inflammation and tissue destruction. Immune responses mediated by T cells and autoantibodies are known to play critical roles in RA. Collagen type II (CII)-induced arthritis (CIA) is a commonly used animal model of human RA. We have previously reported the identification of a new T cell inhibitory molecule CD300c. Here we investigate the ability of recombinant CD300c-IgG2a Fc (CD300c-Ig) fusion protein to prevent and treat CIA.

Methods

Mice were induced to develop CIA by CII and injected with CD300c-Ig or control Ig protein before or after CIA symptoms occur. The mice were examined for CIA clinical and pathological scores, and analysed for the expression of proinflammatory cytokines, the percentage and activ

SUBMITTER: Liu H 

PROVIDER: S-EPMC8889306 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature