Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes.

ABSTRACT:

Importance

Approximately 23 700 US children undergo invasive mechanical ventilation for acute respiratory failure annually, with unknown long-term effects on neurocognitive function.

Objective

To evaluate neurocognitive outcomes of children who survive pediatric intensive care unit (PICU) hospitalization for acute respiratory failure compared with their biological siblings.

Design, setting, and participants

Prospective sibling-matched cohort study conducted at 31 US PICUs and associated neuropsychology testing centers. Patients were 8 years or younger with a Pediatric Cerebral Performance Category score of 1 (normal) before PICU admission and less than or equal to 3 (no worse than moderate neurocognitive dysfunction) at PICU discharge, excluding patients with a histor

SUBMITTER: Watson RS 

PROVIDER: S-EPMC8889465 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature