Novel Therapies in the Treatment of Adult Acute Lymphoblastic Leukemia.

ABSTRACT:

Purpose of review

Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy. Advances in multi-agent chemotherapy have resulted in dramatic improvements in the number of pediatric cases that result in a cure; however, until recently, treatment options for older adults or patients with relapsed and refractory disease were extremely limited. This review seeks to describe in greater detail a number of emerging novel treatment modalities recently approved for this cancer.

Recent findings

In this review, we discuss a number of recently approved novel therapies for ALL, including new approaches with targeted tyrosine kinase inhibitors, novel immune-based therapies including the bispecific antibody blinatumomab and the antibody-drug conjugate inotuzumab ozogamicin, and th

SUBMITTER: Gavralidis A 

PROVIDER: S-EPMC8889501 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature