Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy.

ABSTRACT: An ongoing pandemic of newly emerged SARS-CoV-2 has puzzled many scientists and health care policymakers around the globe. The appearance of the virus was accompanied by several distinct antigenic changes, specifically spike protein which is a key element for host cell entry of virus and major target of currently developing vaccines. Some of these mutations enable the virus to attach to receptors more firmly and easily. Moreover, a growing number of trials are demonstrating higher transmissibility and, in some of them, potentially more serious forms of illness related to novel variants. Some of these lineages, especially the Beta variant of concern, were reported to diminish the neutralizing activity of monoclonal and polyclonal antibodies present in both convalescent and vaccine sera. Thi

SUBMITTER: Rayati Damavandi A 

PROVIDER: S-EPMC8889515 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature