Cytokine and Reward Circuitry Relationships in Treatment-Resistant Depression.

ABSTRACT:

Background

Depressive disorders are linked to dysfunction in reward-related behaviors and corticostriatal reward circuitry. Low-grade dysregulation of the immune system, e.g., elevations in plasma interleukin 6 (IL-6) and tumor necrosis factor α, have been thought to affect corticostriatal reward circuitry. Little is presently known about the degree to which these relationships generalize to patients with treatment-resistant depression (TRD) and/or childhood trauma history.

Methods

Resting-state functional connectivity between the ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC) regions and plasma inflammatory marker levels (IL-6, tumor necrosis factor α) were measured in 74 adults with TRD. Regression analyses examined associations of inflammatory markers wi

SUBMITTER: Rengasamy M 

PROVIDER: S-EPMC8889578 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature