Effects of iron oxide nanoparticles as T₂-MRI contrast agents on reproductive system in male mice.

ABSTRACT: Iron oxide nanoparticles (IONPs)-based contrast agents are widely used for T₂-weighted magnetic resonance imaging (MRI) in clinical diagnosis, highlighting the necessity and importance to evaluate their potential systematic toxicities. Although a few previous studies have documented the toxicity concerns of IONPs to major organs, limited data are available on the potential reproductive toxicity caused by IONPs, especially when administrated via intravenous injection to mimic clinical use of MRI contrast agents. Our study aimed to determine whether exposure to IONPs would affect male reproductive system and cause other related health concerns in ICR mice. The mice were intravenously injected with different concentrations IONPs once followed by routine toxicity tests of major orga

SUBMITTER: Yang H 

PROVIDER: S-EPMC8889634 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature