ZNF703 promotes triple-negative breast cancer cells through cell-cycle signaling and associated with poor prognosis.

ABSTRACT:

Background

The oncogenic drivers of triple-negative breast cancer (TNBC), which is characterized by worst prognosis compared with other subtypes, are poorly understood. Although next-generation sequencing technology has facilitated identifying potential targets, few of the findings have been translated into daily clinical practice. The present study is aimed to explore ZNF703 (Zinc finger 703) function and its underlying mechanism in TNBC.

Methods

ZNF703 expressions in tissue microarray were retrospectively examined by immunohistochemistry. The cell proliferation by SRB assay and colony formation assay, as well as cell cycle distribution by flow cytometry were assessed. The protein levels associated with possible underlying molecular mechanisms were evaluated by western blot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8889678 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature