Enantioselective Addition of Pyrazoles to Dienes*.

ABSTRACT: We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd⁰ -catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.

SUBMITTER: Jiu AY 

PROVIDER: S-EPMC8889753 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature