Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa.

ABSTRACT:

Background

Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures.

Objectives

The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure.

Methods

The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mozambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD, -3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE.

Results

Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p

SUBMITTER: Aguiar L 

PROVIDER: S-EPMC8889833 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature