Limited genomic reconstruction of SARS-CoV-2 transmission history within local epidemiological clusters.

ABSTRACT: A detailed understanding of how and when severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission occurs is crucial for designing effective prevention measures. Other than contact tracing, genome sequencing provides information to help infer who infected whom. However, the effectiveness of the genomic approach in this context depends on both (high enough) mutation and (low enough) transmission rates. Today, the level of resolution that we can obtain when describing SARS-CoV-2 outbreaks using just genomic information alone remains unclear. In order to answer this question, we sequenced forty-nine SARS-CoV-2 patient samples from ten local clusters in NW Spain for which partial epidemiological information was available and inferred transmission history using genomic variants.

SUBMITTER: Gallego-Garcia P 

PROVIDER: S-EPMC8889950 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature