Circadian rhythm in critically ill patients: Insights from the eICU Database.

ABSTRACT:

Objective

To investigate the circadian variation among critically ill patients and its association with clinical characteristics and survival to hospital discharge in a large population of patients in the intensive care unit (ICU).

Methods

Circadian variation was analyzed by fitting cosinor models to hourly blood pressure (BP) measurements in patients of the eICU Collaborative Research Database with an ICU length of stay of at least 3 days. We calculated the amplitude of the 24-hour circadian rhythm and time of the day when BP peaked. We determined the association between amplitude and time of peak BP and severity of illness, medications, mechanical intubation, and survival to hospital discharge.

Results

Among 23,355 patients (mean age 65 years, 55% male), the mean am

SUBMITTER: Beyer SE 

PROVIDER: S-EPMC8890071 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature