Exponential amplification by redox cross-catalysis and unmasking of doubly protected molecular probes.

ABSTRACT: The strength of autocatalytic reactions lies in their ability to provide a powerful means of molecular amplification, which can be very useful for improving the analytical performances of a multitude of analytical and bioanalytical methods. However, one of the major difficulties in designing an efficient autocatalytic amplification system is the requirement for reactants that are both highly reactive and chemically stable in order to avoid limitations imposed by undesirable background amplifications. In the present work, we devised a reaction network based on a redox cross-catalysis principle, in which two catalytic loops activate each other. The first loop, catalyzed by H₂O₂, involves the oxidative deprotection of a naphthylboronate ester probe into a redox-active na

SUBMITTER: Pallu J 

PROVIDER: S-EPMC8890127 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature