MALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-19.

ABSTRACT:

Background

The SARS-CoV-2 infections are still imposing a great public health challenge despite the recent developments in vaccines and therapy. Searching for diagnostic and prognostic methods that are fast, low-cost and accurate are essential for disease control and patient recovery. The MALDI-TOF mass spectrometry technique is rapid, low cost and accurate when compared to other MS methods, thus its use is already reported in the literature for various applications, including microorganism identification, diagnosis and prognosis of diseases.

Methods

Here we developed a prognostic method for COVID-19 using the proteomic profile of saliva samples submitted to MALDI-TOF and machine learning algorithms to train models for COVID-19 severity assessment.

Results

We achieved

SUBMITTER: Lazari LC 

PROVIDER: S-EPMC8890567 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature