Effect of statins on risk and mortality of urologic malignancies: Protocol of an umbrella review.

ABSTRACT:

Introduction

Urologic malignancies are the major causes of morbidity and mortality in men over 40 years old, accounting for more than 20% of all malignant tumors. Several meta-analyses are shown that statin exposure can reduce the morbidity and mortality of various urologic cancers. The adjuvant roles of statin in tumor prevention and anti-tumor activity are now being gradually recognized and have gained attention. Nevertheless, to date, multiple clinical studies and meta-analyses found inconsistent results of their anti-cancer effects. This study aims to evaluate the credibility of the published systematic reviews and meta-analyses that assessed the effects of statin exposure for the incidence and mortality of urologic cancers through an umbrella review.

Methods and analysis

SUBMITTER: Zhai X 

PROVIDER: S-EPMC8890624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature